Experiment

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Description

SaCas9 CRISPRa screens trying to identify which transcription factors (TFs) are responsible for making and maintaining a subset of CD8+ T cells. The same library targeting TF promoters is used with KRAB (CRISPRi) and p300 (CRISRPRa)

Assay

Perturb-Seq

Cell Lines

CD8

Tissue Type

T cell

Assembly

hg38

Data Files

File Name	Description	File Type	File Size	Download

Other Files

File Name	Description	Location	File Type	File Size
crispra.mast.volcano.all.min_thres_4.with_coords.tsv	Defines gRNAs tested. Same file as the data, but including here because defining gRNA is a different purpose than describing regulatory effects those gRNAs cause.	None	File Type	File Size
human_CD8_tcell_tf.grnas.dhs.tsv	This file maps guides to the DHS they target	None	File Type	File Size
features.tsv	This file maps gene names (in the target_gene column of the data file) to ensembl IDs	None	File Type	File Size
crispra.mast.volcano.all.min_thres_4.with_coords.tsv	None	None	File Type	File Size

QC Graphs

Analysis